Prostate-Specific Antigen (PSA), Screening
Label Mnemonic: PSAS
Epic Lab Code: LAB670
Downtime Form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
6240 RCP
Collection Medium:
Plasma Separator Tube 4.5 mL
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection containers.
3 mL whole blood in light green top or TWO Microtainer® devices.
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
1 hour (upon receipt in laboratory)
Reference Range:
Age Reference Range Up to 50 0.00-2.50 ng/mL 50 - 59 0.00-3.50 ng/mL 60 - 69 0.00-4.50 ng/mL > 70 0.00-6.50 ng/mL Age specific normal values from the literature for PSA are provided as a guide only. No one decision level is appropriate when utilizing PSA in screening situation. Age, family history, previous values, and other factors should be used in decisions involving PSA values.
This assay may be significantly impacted by high-dose biotin (>5 mg dose) taken within previous 12 hours. High concentrations of biotin may lead to falsely decreased results. These concentrations may be found in patients taking over-the-counter supplements with biotin content much higher than nutritional requirements for biotin. Specimens should not be collected until at least 12 hours after the last dose.

See: "PSA, Total" to order monitoring PSA test. PSA measurement used in conjunction with DRE (digital rectal exam) is indicated as an aid for the detection of prostate cancer in men aged 50 years or older, must be identified as PSA for screening. It is also useful in monitoring patients with known prostate cancer. PSA is specific to the prostate gland and is present in normal, hyperplastic and neoplastic prostatic epithelium. Plasma elevations are detected in not only prostate carcinoma, but also in benign prostatic hypertrophy and inflammatory conditions of the prostate and adjacent genitourinary tissues. Diagnosis of prostate cancer requires biopsy and histopathologic examination.
Electrochemiluminescence Immunoassay
CPT Code:
CPT codes: G0103, 84153
See Additional Information:
Biotin Interference with Immunoassays