Fluorescence In-Situ Hybridization (FISH-Prenatal-Aneuploidy/Microdeletion)
Label Mnemonic: ANEUPO
Epic Lab Code: CYT54
Downtime Form: C-12 Cytogenetics Request
Shivanand R. Patil Cytogenetics & Molecular Laboratory (Dept. of Pediatrics)
W-101 GH
356-3877 (Laboratory)
Specimen(s):
Amniocytes, Chorionic Villi
Minimum:
>5 mL is recommended, but will not reject if <5mL

Specimen obtained by referring staff physician. Collect specimen using sterile technique. DO NOT FREEZE OR CENTRIFUGE THE SPECIMEN. Contact the Cytogenetics lab with questions. Label tubes with patient name and medical record number.
Delivery Instructions:
Submit specimen to laboratory as soon as possible after collection.
Testing Schedule:
Specimens accepted in the lab Monday-Friday, 0800-1700. After hours specimens should be taken to specimen control and a message left on the lab voice mail. In the case of an emergency, follow the instructions on the lab voice mail.
Turn Around Time:
Aneuploidy results will be reported within two-three days and the final written report in five days for the aneuploidy screening. For microdeletion studies results will be reported in eight days.
Reference Range:
Male: X and Y probe signals Female: two X probe signals The reference range varies for each probe (set).
Comments:
This test can be used as an adjunct to chromosomal analysis for aneuploidy screening on interphase nuclei and on chromosomes for detection of submicroscopic/cryptic rearrangements in certain congenital disorders.

Probes currently available include:
Aneuvysion (aneuploidy screening for 21,18,13,X and Y)
TUPLE 1 (del 22q for CHD)

Call laboratory for additional information or requests.

Shivanand R. Patil Cytogenetics & Molecular Laboratory Website
Methodology:
Fluorescence In-Situ Hybridization (FISH)
CPT Code:
88271 x # of probes
88273 x # of probes
88275 x # enumeration probes
88291
 
See also:
Chromosomal Analysis, Amniotic Fluid
 
See Additional Information:
Cytogenetics and Molecular Testing