|Downtime form:||A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery|
|Plasma Separator Tube 4.5 mL|
Males (18+ years) 11 - 43 pg/mL Females, non-pregnant Follicular Phase 12 - 233 pg/mL Ovulation Phase 41 - 398 pg/mL Luteal Phase 22 - 341 pg/mL Postmenopause <5 - 138 pg/mL Pregnancy 1st Trimester 154 - 3,243 pg/mL 2nd Trimester 1,561 - 21,280 pg/mL 3rd Trimester 8,525 - >30,000 pg/mL Children (1-10 years) Boys <5 - 20 pg/mL Girls 6 - 27 pg/mL
Assay methodology changed to Roche Diagnostics Estradiol III assay on April 20, 2015. Adult reference ranges updated as part of change in methodology. Adult male reference range further updated on March 7, 2017.
This test is also performed in the Iowa River Landing (IRL) clinical laboratory (for specimens drawn at that site).
The estradiol assay shows significant cross-reactivity with fulvestrant, a medication used to treat breast cancer. Contact commercial mailouts (319-356-8593) if estradiol measurement is needed in a patient currently receiving fulvestrant. In rare cases interference due to extremely high titers of antibodies to streptavidin and ruthenium can occur. Estradiol III contains additives which minimize these effects. For diagnostic purposes, the Estradiol III findings should always be assessed in conjunction with the patient's medical history, clinical examination and other findings.
Biotin Interference with Immunoassays