Sulfonylurea Hypoglycemics Drug Levels

Label Mnemonic:	SUREAS
Epic code:	LAB4113
Downtime form:	A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred Minimum: 1 mL serum
Absolute Minimum: 0.4 mL serum

Rejection Criteria:

Separator tubes.

Testing Schedule:

Sundays, Tuesdays and Thursdays

Turn Around Time:

1-6 days upon receipt at reference laboratory

Reference Range:

Drug        Cutoff Concentration
Glyburide          5 ng/mL
Glimepiride        5 ng/mL
Glipizide          5 ng/mL
Repaglinide        5 ng/mL
Nateglinide        5 ng/mL
Chlorpropamide     100 ng/mL
Tolazamide         100 ng/mL
Tolbutamide        100 ng/mL
Rosiglitazone      40 ng/mL
Pioglitazone       40 ng/mL

Interpretive Data:

This assay is used to evaluate hypoglycemia that may be caused from the ingestion of sulfonylurea drugs. Hypoglycemic drugs are detected (present) in this assay if the drug concentration is greater than the limit of detection (cut-off). The presence of hypoglycemic drug(s) indicates a recent ingestion.

Comments:

Preferred test for evaluating if etiology of hypoglycemia is sulfonylurea ingestion.

Methodology:

Qualitative Liquid Chromatography-Tandem Mass Spectrometry

CPT Code:

80377