Methylmalonic Acid
Label Mnemonic: MMAUR
Epic Lab Code: LAB3601
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Urine (24 hr or random) More information
Specimen Instructions:
Refrigerate during collection in plastic container.
Collection Medium:
Urine - 24 hour/timed plastic urine container
Minimum:
Preferred Minimum: 4 mL urine from a well-mixed 24-hour or random urine collection; refrigerated during collection/ submission to laboratory.
Rejection Criteria:
Room temperature specimens.
Delivery Instructions:
Submit refrigerated specimen to laboratory as soon as possible after collection period is completed.
Turn Around Time:
1-3 days upon receipt at reference laboratory.
Reference Range:
Components Reference Interval Methylmalonic Acid, Urine 0.0-3.6 mmol/mol CRT Creatinine (24-hour) Male Female 3-8 yrs: 140-700 mg/d 3-8 yrs: 140-700 mg/d 9-12 yrs: 300-1300 mg/d 9-12 yrs: 300-1300 mg/d 13-17 yrs: 500-2300 mg/d 13-17 yrs: 400-1600 mg/d 18-50 yrs: 1000-2500mg/d 18-50 yrs: 700-1600 mg/d 51-80 yrs: 800-2100 mg/d 51-80 yrs: 500-1400 mg/d 81 yrs+: 600-2000 mg/d 81 yrs+: 400-1300 mg/d
Interpretive Data:
Elevated urinary methylmalonic acid is an early and sensitive indicator of vitamin B12 (cobalamin) deficiency. This test can also be used to monitor patients with methylmalonic aciduria. Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history.
Methodology:
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
CPT Code:
83921