Streptozyme, Reflex to Titer
Label Mnemonic: SZYME
Epic Lab Code: LAB4098
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum or Plasma
Collection Medium:
Red top tube 5 mL (Clot Activator)
Alternate Collection Media:
Lavender top tube 3 mL (EDTA)
Minimum:
Preferred Minimum: 1 mL serum or plasma
Absolute Minimum: 0.5 mL serum or plasma
Delivery Instructions:
Deliver to laboratory within 1 hour of collection.
Turn Around Time:
1-4 days upon receipt at reference laboratory
Reference Range:
Streptozyme Screen - None Detected
Comments:
Detection of multiple antibodies to extracellular antigens of streptococcus with streptozyme is of some diagnostic value but should never replace more standard tests such as streptolysin O antibody (ASO) or DNase-B antibody. These antibodies may be detected in patients after streptococcal pharyngitis, rheumatic fever, pyoderma, glomerulonephritis, and other related conditions. In evaluating a patient with suspected acute rheumatic fever or nephritis, determination of ASO, DNAse-B antibody, and streptozyme will likely yield a positive result in 92-98 percent of cases.
Methodology:
Semi-Quantitative Hemagglutination
CPT Code:
86403 Streptococcus screen; 86406 Streptococcus titer
  (if reflexed from positive screening test); all positive
  results for screening will be titered at an additional charge.
 
See also:
Antistreptolysin O, Serum
Dnase B Antibody, Serum