Copper
Label Mnemonic: CUS
Epic Lab Code: LAB2921
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Blood
Specimen Instructions:
Centrifuge and pour off plasma into reference laboratory Trace Element-Free Transport Tube ASAP. Do not allow plasma to remain on cells. Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, nonessential over-the-counter medications (upon the advice of their physician). Royal Blue K2 EDTA tubes are available from Specimen Control, 6240 RCP.
Collection Medium:
Royal Blue K2 EDTA tube
Minimum:
Preferred Minimum: 2 mL plasma drawn in K2 EDTA royal blue tube
Rejection Criteria:
Separator tubes and specimens that are not separated from the red cells or clot within 6 hours of blood draw.
Turn Around Time:
1-2 days upon receipt at reference laboratory
Reference Range:
Age Male Female 0-10 years 75-153 μg/dL 75-153 μg/dL 11 years-12 years 64-132 μg/dL 64-132 μg/dL 13 years-18 years 57-129 μg/dL 57-129 μg/dL 19 years and older 70-140 μg/dL 80-155 μg/dL
Interpretive Data:
Serum copper may be elevated with infection, inflammation, stress, and copper supplementation. In females, elevated copper may also be caused by oral contraceptives and pregnancy (concentrations may be elevated up to 3 times normal during the third trimester).

Serum copper may be reduced by use of corticosteroids and zinc and by malnutrition or malabsorption.
Comments:
Elevated results from noncertified trace element-free tubes may be due to contamination. Elevated concentrations of trace elements in serum should be confirmed with a second specimen collected in a trace element- free tube, such as royal blue sterile tube (no additive).
Methodology:
Quantitative Inductively Coupled Plasma/Mass Spectrometry
CPT Code:
82525