Copper
Label Mnemonic: CUU
Epic Lab Code: LAB380
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
24 hr Urine More information
Specimen Instructions:
Refrigerate during 24 hr collection in plastic container. Reference laboratory studies indicate that refrigeration of urine alone, during and after collection, preserves specimens adequately, if tested within 14 days of collection.

Patient Prep: Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non- essential over-the-counter medications (upon the advice of their physician). High concentrations of iodine may interfere with elemental testing. Abstinence from iodine-containing medications or contrast agents for at least 1 month prior to collecting specimens for elemental testing is recommended.
Collection Medium:
Urine - 24 hour/timed plastic urine container
Minimum:
Preferred Minimum: 8 mL urine from a well-mixed, refrigerated, 24 hr urine collection.
Absolute Minimum: 1 mL urine from a well-mixed, refrigerated, 24 hr urine collection.
Rejection Criteria:
Urine collected within 48 hours after administration of a gadolinium (Gd) containing contrast media (may occur with MRI studies). Acid preserved urine.
Turn Around Time:
1-3 days upon receipt at reference laboratory
Reference Range:
Copper, Urine-per volume: 0.3-3.2 μg/dL Copper, Urine-per 24-hour: 3.0-45.0 μg/d Copper, Urine-ratio to CRT: 10.0-45.0 μg/gCRT Creatinine, Urine - per 24-hour Male 3-8 years: 140-700 mg/d 9-12 years: 300-1300 mg/d 13-17 years: 500-2300 mg/d 18-50 years: 1000-2500 mg/d 51-80 years: 800-2100 mg/d 81 years and older: 600-2000 mg/d Female 3-8 years: 140-700 mg/d 9-12 years: 300-1300 mg/d 13-17 years: 400-1600 mg/d 18-50 years: 700-1600 mg/d 51-80 years: 500-1400 mg/d 81 years and older: 400-1300 mg/d Copper per gram of creatinine - No reference interval (μg/g crt)
Interpretive Data:
Individuals with symptomatic Wilson disease usually excrete more than 100 ug copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens. Although random specimens may contain diagnostic information, a 24-hour collection is a more consistent indicator of copper urine.
Methodology:
Quantitative Inductively Coupled Plasma-Mass Spectrometry
CPT Code:
82525