N-Telopeptide, Cross-Linked

Label Mnemonic:	NTP
Epic code:	LAB3729
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Urine More information

Specimen Instructions:

Refrigerate during 24 hr collection in plastic container.

Patient Prep: For monitoring therapy, a baseline sample should be collected prior to initiation of therapy. Subsequent samples for comparison should be collected at the same time of day as the baseline sample.

Collection Medium:

Urine - 24 hour/timed plastic urine container

Minimum:

Preferred Minimum: 1.0 mL
Absolute Minimum 0.5 mL

Collect second morning void or 24 hr urine. Sample must be refrigerated during collection and submission to laboratory. No preservative.

Rejection Criteria:

Specimens contaminated with blood or having extensive hemolysis.

Turn Around Time:

1-4 days upon receipt at reference laboratory

Reference Range:

Age                   Male                         Female
7-9 yrs       167-578 nM BCE/mM creatinine 201-626 nM BCE/mM creatinine
10-12 yrs     152-505 nM BCE/mM creatinine 173-728 nM BCE/mM creatinine
13-15 yrs     103-776 nM BCE/mM creatinine  38-515 nM BCE/mM creatinine
16-17 yrs      34-313 nM BCE/mM creatinine  20-144 nM BCE/mM creatinine
18 yrs & older  21-83 nM BCE/mM creatinine
Premenopausal                               17-94 nM BCE/mM creatinine
Postmenopausal                              26-124 nM BCE/mM 
creatinine

Interpretive Data:

NTx Units=nM BCE/mM creatinine

A decrease of 30-40% from the NTx baseline after three months of therapy is a typical response to anti-resorptive therapy.

NTx=Cross-linked N-telopeptide of Type I Collagen
BCE=Bone Collagen Equivalent

Methodology:

Quantitative Chemiluminescent Immunoassay

CPT Code:

82523

See Additional Information:
Urine Tests Requiring no Preservatives
Urine Tests Requiring Preservatives, Refrigeration or Special Containers