Clomipramine & Metabolite Drug Level
Label Mnemonic: CLOM
Epic Lab Code: LAB2880
Downtime Form: A-1a Therapeutic Drug Assay Requisition
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred Minimum: 1.0 mL serum
Rejection Criteria:
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Delivery Instructions:
Deliver to laboratory within 1 hour of collection.
Turn Around Time:
1-5 days upon receipt in reference laboratory.
Reference Range:
Therapeutic Range: Total clomipramine and norclomipramine: 220 - 500 ng/mL Toxic: > 900 ng/mL
Interpretive Data:
The therapeutic range listed relates to the antidepressant characteristics of the drug. A therapeutic range for treating obsessive compulsive disorder is not well established. Toxic concentrations may cause anticholinergic effects, CNS depression, cardiac abnormalities, seizures and hypotension.
Methodology:
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
CPT Code:
80335