Clomipramine & Metabolite Drug Level

Label Mnemonic:	CLOM
Epic code:	LAB2880
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred Minimum: 1.0 mL serum

Rejection Criteria:

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Delivery Instructions:

Deliver to laboratory within 1 hour of collection.

Turn Around Time:

1-7 days upon receipt in reference laboratory.

Reference Range:

Therapeutic Range:
 Total clomipramine and norclomipramine:  220 - 500 ng/mL

Toxic: > 900 ng/mL

Interpretive Data:

The therapeutic range listed relates to the antidepressant characteristics of the drug. A therapeutic range for treating obsessive compulsive disorder is not well established. Toxic concentrations may cause anticholinergic effects, CNS depression, cardiac abnormalities, seizures and hypotension.

Methodology:

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

CPT Code:

80335