2,3-dinor 11B-Prostaglandin F2a
Label Mnemonic: 23BPGRU
Epic code: LAB9173
Downtime form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mailout Laboratory
6240-8 RCP
Random Urine
Specimen Instructions:
Patient Preparation: Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAID) may have decreased concentrations of prostaglandin F2 alpha. If possible, discontinue for 2 weeks or 72 hours, respectively, prior to collecting a specimen.
Collection Medium:
Yellow top round bottom tube (no additive)
5 mL random urine
Testing Schedule:
Test performed on Mondays and Thursdays
Turn Around Time:
2 - 6 days upon receipt at reference laboratory
Reference Range:
<1802 pg/mg creatinine
Interpretive Data:
Elevated urine 2,3-dinor-11beta-prostaglandin F2 alpha is consistent with systemic mastocytosis.
This test is useful for screening for mast cell activation disorders including systemic mastocytosis using random urine specimens.

Ordering Guidance:
Although a random urine collection is acceptable, the preferred specimen for 2,3-dinor-11beta-prostaglandin F2 alpha analysis is a 24-hour urine collection; order 23BPT / 2,3-Dinor-11 Beta-Prostaglandin F2 Alpha, 24 Hour, Urine.

If ordering this test with NMHR / N-Methylhistamine, Random, Urine, both tests must be ordered under different order numbers. They cannot share an order number.

Elevated levels of 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG) in urine are not specific for systemic mast cell disease and may be found in patients with angioedema, diffuse urticaria, or myeloproliferative diseases in the absence of diffuse mast cell proliferation.

Systemic mast cell disease is a heterogeneous disease, and some patients may not have elevated 2,3 BPG in urine.
R23BP: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
CRETR: Enzymatic Colorimetric Assay
CPT Code:
84150, 82570