TP53 Gene Analysis and Interpretation
| Label Mnemonic: | TP53 |
| Epic code: | LAB8967 |
| Downtime form: | Doctor/Provider Orders - Pathology Molecular |
Molecular Pathology
6240 RCP
384-9568
6240 RCP
384-9568
Specimen(s):
Blood, Bone Marrow Aspirate, Tissue (formalin fixed paraffin embedded)
Collection Medium:
 |
| Pink top tube 6 mL (K2-EDTA) |
Minimum:
Blood: Collect ONE full Pink top EDTA tube, requires a dedicated tube.
Bone Marrow Aspirate: Collect ONE full Pink top EDTA tube, requires a dedicated tube.
One tumor-containing formalin-fixed paraffin embedded tissue block or 10 unstained 4 micron-thick sections on non-plus slides and one H&E stained section from one tumor-containing FFPET block or any or all unstained or stained slides from tumor-containing, fine needle aspirate cytologic preparations. Specimen requires 20% or greater tumor cell content.
Bone Marrow Aspirate: Collect ONE full Pink top EDTA tube, requires a dedicated tube.
One tumor-containing formalin-fixed paraffin embedded tissue block or 10 unstained 4 micron-thick sections on non-plus slides and one H&E stained section from one tumor-containing FFPET block or any or all unstained or stained slides from tumor-containing, fine needle aspirate cytologic preparations. Specimen requires 20% or greater tumor cell content.
Rejection Criteria:
Tumor specimens containing less than 20% tumor cells may be unacceptable.
Testing Schedule:
Twice weekly
Turn Around
Time:
7-10 days
Comments:
TP53 mutations are identified by performing full gene coding sequence analysis.
Methodology:
DNA sequencing by synthesis
CPT Code:
81351
81479 (Medicare Only)
81479 (Medicare Only)