Anti-HMGCR Autoantibody, IgG
| Label Mnemonic: | HMGCR |
| Epic code: | LAB8579 |
| Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
 |
| Red top tube 5 mL (Clot Activator) |
Minimum:
Preferred Minimum: 0.5 mL serum in red top tube
Absolute Minimum: 0.15 mL serum
Absolute Minimum: 0.15 mL serum
Rejection Criteria:
Other body fluids. Contaminated, hemolyzed, grossly icteric, or
severely lipemic specimens.
Turn Around
Time:
1-15 days upon receipt at reference laboratory
Reference Range:
0-19 Units: Negative
Interpretive Data:
IgG antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase
(HMGCR) are mainly associated with necrotizing autoimmune myopathy
(NAM) in a subset of statin-treated patients. Although infrequent,
these antibodies may also be observed in statin-naive patients with
NAM. Strong clinical correlation is recommended in the absence of
muscle fiber necrosis, elevated serum creatine kinase, perimysial
pathology, and/or statin exposure.
Methodology:
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
CPT Code:
83516