Autoimmune Liver Disease Panel
| Label Mnemonic: | ALDP |
| Epic code: | LAB8698 |
| Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
 |
| Red top tube 5 mL (Clot Activator) |
Minimum:
Preferred Minimum: 1.5 mL Serum
Absolute Minimum: 1.0 mL Serum
Absolute Minimum: 1.0 mL Serum
Testing Schedule:
Monday through Friday; 9 am and 4 pm, Saturday; 12 pm
Turn Around
Time:
3 days upon receipt at reference laboratory
Reference Range:
SMOOTH MUSCLE ANTIBODIES
Negative
If positive, results are titered.
Reference values apply to all ages
MITOCHONDRIAL ANTIBODIES (M2)
Negative: <0.1 Units
Borderline: 0.1-0.3 Units
Weakly positive: 0.4-0.9 Units
Positive: > or =1.0 Units
Reference values apply to all ages.
ANTINUCLEAR ANTIBODIES (ANA2)
Negative: < or =1.0 Units
Weakly positive: 1.1-2.9 Units
Positive: 3.0-5.9 Units
Strongly positive: > or =6.0 Units
Reference values apply to all ages.
Negative
If positive, results are titered.
Reference values apply to all ages
MITOCHONDRIAL ANTIBODIES (M2)
Negative: <0.1 Units
Borderline: 0.1-0.3 Units
Weakly positive: 0.4-0.9 Units
Positive: > or =1.0 Units
Reference values apply to all ages.
ANTINUCLEAR ANTIBODIES (ANA2)
Negative: < or =1.0 Units
Weakly positive: 1.1-2.9 Units
Positive: 3.0-5.9 Units
Strongly positive: > or =6.0 Units
Reference values apply to all ages.
Interpretive Data:
The presence of smooth muscle antibodies (SMAs) and/or antinuclear
antibodies (ANAs) is consistent with a diagnosis of chronic autoimmune
hepatitis, in patients with clinical and/or laboratory evidence of
hepatocellular damage.
The presence of anti-mitochondrial antibodies (AMAs) is consistent with a diagnosis of primary biliary cirrhosis, in patients with clinical and/or laboratory evidence of hepatobiliary damage.
The presence of anti-mitochondrial antibodies (AMAs) is consistent with a diagnosis of primary biliary cirrhosis, in patients with clinical and/or laboratory evidence of hepatobiliary damage.
Comments:
Useful for:
Evaluation of patients with suspected autoimmune liver disease, specifically autoimmune hepatitis or primary biliary cirrhosis.
Evaluation of patients with liver disease of unknown etiology.
Evaluation of patients with suspected autoimmune liver disease, specifically autoimmune hepatitis or primary biliary cirrhosis.
Evaluation of patients with liver disease of unknown etiology.
Methodology:
AMA: Enzyme Immunoassay (EIA)
SMA: Indirect Immunofluorescence
ANA2: Enzyme-Linked Immunosorbent Assay (ELISA)
SMA: Indirect Immunofluorescence
ANA2: Enzyme-Linked Immunosorbent Assay (ELISA)
CPT Code:
83516 x1, 86038 x1, 86255 x1
86256-Smooth Muscle Antibodies Titer (if appropriate)
86256-Smooth Muscle Antibodies Titer (if appropriate)