Liver-Kidney Microsome Antibody, IgG
| Label Mnemonic: | LKM |
| Epic code: | LAB8679 |
| Order form: | Epic Req |
| Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
 |
| Red top tube 5 mL (Clot Activator) |
Minimum:
Preferred Minimum: 0.5 mL serum
Absolute Minimum: 0.4 mL serum
Absolute Minimum: 0.4 mL serum
Turn Around
Time:
1 day upon receipt at reference laboratory
Reference Range:
< or =20.0 Units (negative)
20.1-24.9 Units (equivocal)
> or =25.0 Units (positive)
Reference values apply to all ages.
20.1-24.9 Units (equivocal)
> or =25.0 Units (positive)
Reference values apply to all ages.
Interpretive Data:
Seropositivity for anti-LKM-1 antibodies is consistent with a
diagnosis of AIH type 2.
Comments:
Useful For:
Evaluation of patients with liver disease of unknown etiology
Evaluation of patients with suspected autoimmune hepatitis
Cautions:
Serologic tests for autoantibodies, including anti-LKM-1, should not be relied upon exclusively to determine the etiology or prognosis of patients with liver disease.
Anti-LKM-1 antibodies may occur in some patients with chronic hepatitis caused by hepatitis C virus infection. Although the epitopes recognized by anti-LKM-1 antibodies in hepatitis C virus infection are different than in patients with AIH type 2, physicians must use caution in interpreting the results of tests for anti-LKM-1 antibodies in such patients.
Evaluation of patients with liver disease of unknown etiology
Evaluation of patients with suspected autoimmune hepatitis
Cautions:
Serologic tests for autoantibodies, including anti-LKM-1, should not be relied upon exclusively to determine the etiology or prognosis of patients with liver disease.
Anti-LKM-1 antibodies may occur in some patients with chronic hepatitis caused by hepatitis C virus infection. Although the epitopes recognized by anti-LKM-1 antibodies in hepatitis C virus infection are different than in patients with AIH type 2, physicians must use caution in interpreting the results of tests for anti-LKM-1 antibodies in such patients.
Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA)
CPT Code:
86376