Saccharomyces cerevisiae Antibodies, IgG & IgA

Label Mnemonic:	ASCA
Epic code:	LAB8688
Order form:	Epic Req

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred Minimum: 0.5 mL serum
Absolute Minimum: 0.3 mL serum

Rejection Criteria:

Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.

Turn Around Time:

1-2 days upon receipt at reference laboratory

Reference Range:

S. cerevisiae Antibody, IgG
20.0 Units or less - Negative
20.1-24.9 Units - Equivocal
25.0 Units or greater - Positive

S. cerevisiae Antibody, IgA
20.0 Units or less - Negative
20.1-24.9 Units - Equivocal
25.0 Units or greater - Positive

Interpretive Data:

Saccharomyces cerevisiae IgG antibodies are found in 60-70% of Crohn disease (CD) patients and 10-15% of ulcerative colitis (UC) patients. Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients. Detection of both Saccharomyces IgG and IgA antibodies in the same serum specimen is highly specific for CD.

Comments:

This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.

Methodology:

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

CPT Code:

86671 x2