Histoplasma Capsulatum
| Label Mnemonic: | UHIST |
| Epic code: | LAB8672 |
| Order form: | Epic Req |
| Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Urine
Specimen
Instructions:
1. Collect a random urine specimen. 2. No preservative. 3. Excessively bloody or very turbid specimens containing protein, cells, or particulates will be cancelled as they can inhibit the function of the test. 4. Centrifuging to remove particulates is not approved. 5. Specimens with any dyes or unnatural color are not acceptable and will be cancelled.
Collection Medium:
) |
| Urine (Random)-BD Vacutainer®, no additive yellow top |
Minimum:
Preferred Minimum: 5 mL random urine
Absolute Minimum: 2.5 mL random urine
Absolute Minimum: 2.5 mL random urine
Turn Around
Time:
1 day upon receipt at reference laboratory
Reference Range:
HISTOPLASMA ANTIGEN RESULT
Negative
HISTOPLASMA ANTIGEN VALUE
Negative: 0.00-0.10
Indeterminate: 0.11-0.49
Positive: > or =0.50
Negative
HISTOPLASMA ANTIGEN VALUE
Negative: 0.00-0.10
Indeterminate: 0.11-0.49
Positive: > or =0.50
Interpretive Data:
Presence of Histoplasma antigen in urine is indicative of
current or recent infection with H capsulatum.
Declining levels of Histoplasma antigen are indicative of disease regression and can be used to monitor patient response to antifungal therapy. Notably, low-level titers may persist for extended periods of time following appropriate treatment and resolution of infection.
Urine samples with "Indeterminate" results are automatically reflexed to for confirmatory testing. Clinical decisions regarding Histoplasma infection should not be based on an indeterminate result alone. Other laboratory findings, including Histoplasma serology, fungal culture, and molecular tests (eg, RT-PCR) should be considered, alongside clinical presentation and exposure history, to confirm the diagnosis.
The absence of detectable Histoplasma antigen in urine is consistent with the absence of infection. Repeat testing on a fresh urine sample if early acute Histoplasma infection is suspected.
Declining levels of Histoplasma antigen are indicative of disease regression and can be used to monitor patient response to antifungal therapy. Notably, low-level titers may persist for extended periods of time following appropriate treatment and resolution of infection.
Urine samples with "Indeterminate" results are automatically reflexed to for confirmatory testing. Clinical decisions regarding Histoplasma infection should not be based on an indeterminate result alone. Other laboratory findings, including Histoplasma serology, fungal culture, and molecular tests (eg, RT-PCR) should be considered, alongside clinical presentation and exposure history, to confirm the diagnosis.
The absence of detectable Histoplasma antigen in urine is consistent with the absence of infection. Repeat testing on a fresh urine sample if early acute Histoplasma infection is suspected.
Comments:
Useful For:
Aids in the diagnosis of Histoplasma capsulatum infection
Monitoring Histoplasma antigen titers in urine
Cautions:
Cross-reactivity with other fungal infections, including Blastomyces dermatitidis, may occur. Positive results should be correlated with other clinical and laboratory findings (eg, culture, serology).
Low-level positive or indeterminate titers may persist following resolution of infection and completion of appropriate treatment regimen.
Aids in the diagnosis of Histoplasma capsulatum infection
Monitoring Histoplasma antigen titers in urine
Cautions:
Cross-reactivity with other fungal infections, including Blastomyces dermatitidis, may occur. Positive results should be correlated with other clinical and laboratory findings (eg, culture, serology).
Low-level positive or indeterminate titers may persist following resolution of infection and completion of appropriate treatment regimen.
Methodology:
Enzyme Immunoassay (EIA)
CPT Code:
87385