Anti-HMGCR Autoantibodies
Label Mnemonic: FAHMG
Epic Lab Code: LAB8579
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred Minimum: 2 mL serum
Absolute Minimum: 0.5 mL serum
Turn Around Time:
7 days upon receipt at reference laboratory
Reference Range:
Negative: <20 Weak Positive: 20 - 39 Moderate Positive: 40 - 59 Strong Positive: >=60
Interpretive Data:
Anti-HMGCR antibodies are usually found in association with necrotizing myopathy related to statin therapy. However, about 30% of Anti-HMGCR positive patients with necrotizing myopathy have never been exposed to statins. The literature suggests that false positives are extremely rare. As a lab developed test (LDT), approval or clearance by the FDA is not required. This test may be used for clinical purposes and should not be regarded as investigational or for research. Diagnosis Number (%) Pos Polymyositis/Dermatomyositis 2/76(2.6) Systemic Lupus Erythematosis 0/30(0.0) Primary Sjogren's Syndrome 0/30(0.0) Rheumatoid Arthritis 0/30(0.0) Systemic Sclerosis 0/30(0.0) Normal Controls 0/47(0.0)
Comments:
HMGCR Abs (3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase) are associated with necrotizing myopathy that is commonly related to statin exposure.
CPT Code:
83520