Random Urine

Patient Prep: Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure.

Preferred Minimum: 8 mL random urine
Absolute Minimum: 1 mL random urine

Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material.

1-5 days upon receipt at reference laboratory

Copper, Urine: Less than or equal to 3.2 µg/dL
Copper Urine - ratio to CRT: 10.0-45.0 μg/gCRT

Individuals with symptomatic Wilson disease usually excrete more than 100 copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.

Although random specimens may contain diagnostic information, 24-hour collection is a more consistent indicator of elevated copper.

Quantitative Inductively Coupled Plasma-Mass Spectrometry

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