Copper
Label Mnemonic: CUUR
Epic Lab Code: LAB8529
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Random Urine
Specimen Instructions:
Patient Prep: Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non- essential over-the-counter medications (upon the advice of their physician). High concentrations of iodine may interfere with elemental testing. Abstinence from iodine-containing medications or contrast agents for at least 1 month prior to collecting specimens for elemental testing is recommended.
Collection Medium:
Urine (Random)-BD Vacutainer®, no additive yellow top
Minimum:
Preferred Minimum: 8 mL random urine
Absolute Minimum: 1 mL random urine
Rejection Criteria:
Urine collected within 48 hours after administration of a gadolinium (Gd) containing contrast media (may occur with MRI studies). Acid preserved urine.
Turn Around Time:
1-3 days upon receipt at reference laboratory
Reference Range:
Copper, Urine - per volume: 0.3-3.2 μg/dL
Copper Urine - ratio to CRT: 10.0-45.0 μg/gCRT
Interpretive Data:
Individuals with symptomatic Wilson disease usually excrete more than 100 copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.

Although random specimens may contain diagnostic information, 24-hour collection is a more consistent indicator of elevated copper.
Methodology:
Quantitative Inductively Coupled Plasma-Mass Spectrometry
CPT Code:
82525