Bartonella Antibody Panel, IgG and IgM
Label Mnemonic: BART
Epic Lab Code: LAB8517
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred Minimum: 0.5 mL serum
Absolute Minimum: 0.15 mL serum
Turn Around Time:
1-3 days upon receipt at reference laboratory
Reference Range:
Bartonella henselae
IgG: <1:128
IgM: <1:20

Bartonella quintana
IgG: <1:128
IgM: <1:20
Interpretive Data:
A positive immunofluorescence assay (IFA) IgM (titer >1:20) suggests a current infection with either Bartonella henselae or Barteonella quintana.

A positive IgG (titer >1:128) suggests a current or previous infection. Increases in IgG titers in serial specimens would indicate an active infection.

Normal serum specimens usually have an IgG titer of <1:128. However, 5% to 10% of healthy controls exhibit a Bartonella henselae and Bartonella quintana titer of 1:128. No healthy controls showed titers of > or =1:256. IgM titers from normal serum were found to be <1:20. IgM titers at > or =1:20 have not been seen in the normal population.

Culture should also be considered, but this may not be an optimal method due to slow growth and fastidious nature of the organism.
Comments:
Useful for:
Rapid diagnosis of Bartonella infection, especially in the context of a cat scratch or histopathology showing typical features of stellate microabscesses and/or positive Warthin-Starry stain.

Cautions:
IgG cross-reactivity between Bartonella henselae and Bartonella quintana has been reported. However, the infecting species will usually have the higher titer.

IgM cross-reactivity is usually not seen. Significant cross-reactions have been reported between Bartonella species and Chlamydia species.

Print, complete, and submit the Neurology Test Request Form from Mayo Medical Laboratories with the sample(s) and the A-1a Miscellaneous Request or Epic Req.
Methodology:
Immunofluorescence Assay (IFA)
CPT Code:
86611(x4)