MLH1 Promoter Methylation, Paraffin
Label Mnemonic: MLH1PCR
Epic Lab Code: LAB8449
Downtime Form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mail-out Laboratory
5231 RCP
Tumor Tissue
Specimen Instructions:
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block or 5 unstained 5-micron slides. (Min: 3 slides) Transport block and/or slide (s) in a tissue transport kit. Store and send at room temperature.
Rejection Criteria:
Frozen specimens. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). Decalcified specimens.
Turn Around Time:
10-12 days upon receipt at reference laboratory
Interpretive Data:
Refer to report.
This test distinguishes between Lynch syndrome and sporadic tumors with loss of MLH1.
Real-Time Polymerase Chain Reaction/Fluorescence Resonance Energy Transfer
CPT Code:
88381, 81288