Clobazam Quantitative

Label Mnemonic:	CLOBA
Epic code:	LAB8416
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred Minimum: 2 mL serum
Absolute Minimum: 0.3 mL serum

Rejection Criteria:

Gel separator tubes. Hemolyzed specimens.

Turn Around Time:

1-6 days upon receipt at reference laboratory

Reference Range:

By report

Available    Components            Therapeutic and Toxic Range
Separately
----------------------------------------------------------------------
No           Clobazam	           Therapeutic Range: 30 – 300 ng/mL                                                               
                                   Toxic: Greater than 500 ng/mL

No           N-Desmethylclobazam   Therapeutic Range: 300 – 3000 ng/mL                                                                             
                                   Toxic: Greater than 5000 ng/mL

Interpretive Data:

Clobazam is a benzodiazepine drug indicated for adjunctive treatment for seizures associated with Lennox-Gastaut syndrome in patients 2 years and older. The therapeutic range is based on serum, pre-dose (trough) draw collection at steady-state concentration. The pharmacokinetics of clobazam are influenced by drug-drug interactions and by poor CYP2C19 metabolism. Adverse effects may include constipation, somnolence, sedation, and skin rash. The concomitant use of clobazam with other central nervous system (CNS) depressants may increase the risk of somnolence and sedation.

Methodology:

Quantitative High Performance Liquid Chromatography/Tandem Mass Spectrometry

CPT Code:

80339