Integrated Second Sample Screen - Iowa Maternal Screening
Label Mnemonic: ISIMS
Epic Lab Code: LAB8339
Downtime Form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mail-out Laboratory
5231 RCP
Specimen Instructions:
Collect between 15 weeks-20 weeks 6 days.

Provide patient weight (kg), race, and number of fetuses. Also note if the patient is taking insulin for diabetes and whether the patient or her partner had a neural tube defect (NTD) or if either has had a previous pregnancy with a NTD.

Refrigerate specimen if not transported within 24 hours of collection to reference laboratory.
Collection Medium:
Red top tube 5 mL (Clot Activator)
3 mL whole blood in Red Top Tube or 1 mL serum
Rejection Criteria:
Plasma or specimen older than 9 days. Sample not collected within the required gestational age range.
Delivery Instructions:
Deliver to laboratory after collection.
Turn Around Time:
3-5 days upon receipt at reference laboratory
Reference Range:
By report - AFP, hCG, Estriol, Inhibin A from this sample, and PAPP-A from previous sample, calculated Multiples of the Median (MoMs) based on gestational age.
This test is the second sample of a two-part test. Testing requires that collection of Integrated First Sample Screen - Iowa Maternal Screening, LAB8338, was submitted in the 1st trimester. Screening test for DS, T18, and open NTD determined using a combination of 1st and 2nd trimester markers with or without a 1st trimester nuchal translucency (NT) measurement.

This test cannot be performed on multiples.
Quantitative Chemiluminescent Immunoassay
CPT Code:
82105, 84702, 82677, 86336, 84163