IDH1 & IDH2 Mutation Analysis
Label Mnemonic: IDH12
Epic Lab Code: LAB8289
Downtime Form: A-1a Doctor/Provider Orders - Pathology Molecular
Molecular Pathology
6004 BT GH
Peripheral Blood
Specimen Instructions:
Testing requires dedicated collection tube.
Collection Medium:
Pink top tube 6 mL (K2-EDTA)
Collect 3 mL blood in Pink top tube.
Testing Schedule:
Turn Around Time:
21 days
Sequence analysis is performed for exons 4 and 6 of IDH1 and exon4 of IDH2 and includes detection of the common variants; IDH1 p.R132C (394C>T), IDH2 p.R140Q (c.419G>A), and IDH2 p.R172K (c.515G>A). These variants may be detected in several different tumor types. However, peripheral blood and bone marrow testing is primarily indicated for patients with hematologic malignancy including acute myeloid leukemia.
DNA sequencing by synthesis, semiconductor technology, Ion Personal Genomics Machine
CPT Code:
81120 - IDH1, 81121 - IDH2