Liver Fibrosis, FibroTest
Label Mnemonic: FLFFT
Epic Lab Code: LAB8382
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Specimen Instructions:
Note: 1. Overnight fast is preferred. 2. Not available for patients less than TWO years of age.
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Draw TWO red top tubes. Separate serum from cells within one hour and send TWO tubes of serum, 2.5 mL in first tube and 1.0 mL in second tube frozen in plastic screw-capped tubes. Ship frozen.
Preferred Minimum: 3.5 mL serum
Absolute Minimum: 2 mL serum
Delivery Instructions:
Deliver to laboratory immediately after collection. Critical frozen.
Testing Schedule:
Test performed Tuesday through Saturday
Turn Around Time:
2 - 4 days upon receipt at reference laboratory
Reference Range:
Fibrosis Score 0.0 - 1.00 Fibrosis Stage Fibrosis Interpretation Necroinflammat Act Score 0.00 - 1.00 Necroinflammat Act Grade Necroinflammat Interp Alpha-2-Macroglobins <18 Years Not established >or= 18 Years 106 - 279 mg/dL Haptoglobin <18 Years Not established >or= 18 Years 43 - 212 mg/dL Apolioprotein A-1 Males: <18 Years Not established >or= 18 Years 94 - 176 mg/dL Females: <18 Years Not established >or= 18 Years 101 - 198 mg/dL Total Bilirubin 2 - 9 Years 0.2 - 0.8 mg/dL 10 - 19 Years 0.2 - 1.1 mg/dL >or= 20 Years 0.2 - 1.2 mg/dL GGT Males: 2 - 12 Years 3 - 22 U/L 13 - 15 Years 8 - 32 U/L 16 - 19 Years 9 - 31 U/L 20 - 29 Years 3 - 70 U/L 30 - 39 Years 3 - 90 U/L 40 - 54 Years 3 - 95 U/L 55 - 59 Years 3 - 85 U/L >or= 60 Years 3 - 70 U/L Females: 2 - 12 Years 3 - 22 U/L 13 - 1 Years 7 - 18 U/L 16 - 19 Years 6 - 26 U/L 20 - 29 Years 3 - 40 U/L 30 - 39 Years 3 - 50 U/L 40 - 49 Years 3 - 55 U/L 50 - 59 Years 3 - 70 U/L >or= 60 Years 3 - 65 U/L Alanine Aminotransferase (ALT) 2 - 3 Years Male: 5 - 30 U/L Female: 5 - 30 U/L 4 - 12 Years Male: 8 - 30 U/L Female: 8 - 24 U/L 13 - 15 Years Male: 7 - 32 U/L Female: 5 - 32 U/L 16 - 19 Years Male: 8 - 46 U/L Female: 5 - 32 U/L >or= 20 Years Male: 9 - 46 U/L Female: 6 - 29 U/L
Interpretive Data:
The reliability of results is dependent on compliance with the pre- analytical and analytical conditions recommended by BioPredictive. The Tests have to be deferred for: acute hemolysis, acute hepatitis, acute inflammation, extra hepatic cholestasis. The advice of a specialist should be sought for interpretation in chronic hemolysis and Gilbert's syndrome. The Test interpretation is not validated in liver transplant patients. Isolated extreme values of one of the components should lead to caution in interpreting the results. In case of discordance between a biopsy result and a Test, it is recommended to seek the advice of a specialist. The cause of these discordances could be due to a flaw of the Test or to a flaw in the biopsy: i.e. a liver biopsy has a 33% variability rate for one fibrosis stage. FibroTest is interpretable for chronic hepatitis B and C, alcoholic and non-alcoholic steatosis. ActiTest is interpretable for chronic hepatitis B and C.
Methodology:
Nephelometry and Spectrophotometry
CPT Code:
82172 Apolipoproteinz
82247 Bilirubin, total
82977 GGT
83010 Haptoglobin
83883 Alpha2macroglobulins, quantitative
84460 ALT