Commercial Mail-out Laboratory
No specific patient preparation is required as Amyloid B-Protein is
increased by the quantity and density of plaques.
Collect 2 mL CSF in sterile container.
20- 80 pg/mL
Amyloid B-Protein is a peptide that ranges in size from 28-43 amino
acids. Most fragments have the same biological activity as the whole
molecule. Amyloid B-Protein causes vascular and cerebral plaque
formation. Insoluble fibrils of Amyloid B-Protein accumulate in adrenal
blood vessels and un neutritic plaques. Occurrence of plaques are
present in normal brain but in a much less dense degree as in
Alzheimer's disease patients. Amyloid B-Protein is also found in
elevated levels in patients with Down's Syndrome. Substance P has been
found to counteract the effects of Amyloid B-Protein.
Amyloid Protein is measured by a specific radioimmunoassay procedure
that measures all fragments from 1-40 amino acids.