CSF

No specific patient preparation is required as Amyloid B-Protein is increased by the quantity and density of plaques.

Collect 2 mL CSF in sterile container.

20- 80 pg/mL

Amyloid B-Protein is a peptide that ranges in size from 28-43 amino acids. Most fragments have the same biological activity as the whole molecule. Amyloid B-Protein causes vascular and cerebral plaque formation. Insoluble fibrils of Amyloid B-Protein accumulate in adrenal blood vessels and un neutritic plaques. Occurrence of plaques are present in normal brain but in a much less dense degree as in Alzheimer's disease patients. Amyloid B-Protein is also found in elevated levels in patients with Down's Syndrome. Substance P has been found to counteract the effects of Amyloid B-Protein.

Amyloid Protein is measured by a specific radioimmunoassay procedure that measures all fragments from 1-40 amino acids.

83519