Parietal Cell Antibodies, IgG
Label Mnemonic: PCAB
Epic code: LAB8204
Downtime form: Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mailout Laboratory
6240-8 RCP
Collection Medium:
Red top tube 5 mL (Clot Activator)
0.5 mL serum
Turn Around Time:
1-4 days upon receipt at reference laboratory
Reference Range:
Negative: < or =20.0 Units
Equivocal: 20.1-24.9 Units
Positive: > or =25.0 Units
Reference values apply to all ages.
Interpretive Data:
A positive result indicates the presence of IgG antibodies to H(+)/K(+) ATPase and suggests the possibility of pernicious anemia (PA) or a related autoimmune disease.

A negative result indicates no detectable IgG antibodies to H(+)/K(+) ATPase; it does not rule out PA.

An equivocal result is indeterminate.
Useful For: Evaluating patients suspected of having pernicious anemia or immune-mediated deficiency of vitamin B12 with or without megaloblastic anemia.

The presence of immune complexes or other immunoglobulin aggregates in the patient specimen may cause an increased non-specific binding and produce false-positive results in this assay.

A negative result does not rule out the presence of parietal cell antibodies; the concentration of antibody may be below the detection limit of the assay.

A positive result only indicates the presence of antibody to H(+)/K(+) ATPase and does not necessarily indicate the presence of autoimmune disease or other diseases.

The assay performance has not been established for pediatric patients.

Results of this assay should be used in conjunction with clinical findings and other serological tests.

The assay performance characteristics have not been established for matrices other than serum.
Enzyme-Linked Immunosorbent Assay (ELISA)
CPT Code: