Zinc Transporter 8 Antibody
Label Mnemonic: ZN8AB
Epic Lab Code: LAB8114
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred Minimum: 0.5 mL serum
Absolute Minimum: 0.1 mL serum
Rejection Criteria:
Plasma. Grossly hemolyzed or severely lipemic specimens.
Turn Around Time:
1-8 days upon receipt at reference laboratory
Reference Range:
0.0-15.0 Kronus Units/mL
Interpretive Data:
A value greater than 15.0 Kronus Units/mL is considered positive for the Zinc Transporter 8 Antibody (ZnT8). Kronus units are arbitrary. Kronus Units = U/mL. This assay is intended for the semi-quantitative determination of antibodies to ZnT8 in human serum. Results should be interpreted within the context of clinical symptoms.
Comments:
Test not recommended in routine evaluation or management of diabetes mellitus (DM).
Test Limitations:
•Negative test results do not rule out autoimmune diabetes
   -Autoantibody response varies in individuals

•Presence of autoantibodies is predictive of DM1, but not all individuals
 with antibodies will develop DM1

•Not useful in DM monitoring

•Insulin antibody RIA test does not differentiate between endogenous or
 exogenous form of insulin
Methodology:
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
CPT Code:
83516