Platelet Reactivity Units (P2Y12)
Label Mnemonic: PRU
Epic Lab Code: LAB8075
Downtime Form: A-1a General Laboratory Requisition
Hematology
6240 RCP
356-3527
Specimen(s):
Whole Blood
Specimen Instructions:
Must be drawn in special sodium citrate tubes. Call Tech Services (356-3527) for collection kit.
Collection Medium:
Special Coagulation Tube
Minimum:
Must be collected in a (2 mL) special collection tube.
Rejection Criteria:
If specimen is over 4 hours old and not drawn in special collection tubes.
Delivery Instructions:
Must be hand-delivered to laboratory within 2 hours of collection; specimen cannot be sent using pneumatic tube system. Keep at room temperature.
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
1 hour (upon receipt in laboratory)
Reference Range:
182-335 RU
Interpretive Data:
Values less than the lower limit (182) are highly specific for a P2Y12 inhibitor effect.

Patients who have been treated with Glycoprotein IIb/IIIa inhibitors should not be tested until platelet function has recovered. This time period is approximately 14 days after discontinuation of abciximab (ReoPro) and up to 48 hours after discontinuation of eptifibatide (Integrilin) and tirofiban (Aggrastat).
Comments:
The following drugs are P2Y12 inhibitors: Clopidogrel (Plavix), Ticlopidine (Ticlid), Prasugrel (Effient), and Ticagrelor (Brilinta).
Test Limitations:
Improper sample collection (platelet activation) or patient's exposure to GPIIb/IIIa inhibitors within: 48 hours of eptifibatide or 14 days of abciximab.
Methodology:
The VerifyNow system incorporates ADP induced aggregation - to determine extent of platelet aggregation in the presence of P2Y12 inhibitors.
CPT Code:
85576