TMA Genetic Renal Panel
Label Mnemonic: TMAMORL
Epic Lab Code: LAB8233
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Whole Blood
Specimen Instructions:
Samples may be refrigerated if delivery is delayed.
Collection Medium:
and
Pink top tube 6 mL (K2-EDTA) Pink top tube 6 mL (K2-EDTA)
Minimum:
Adult Minimum: 8-10 mL whole blood in TWO Pink tope tubes (K2-EDTA)
Pediatric Minimum: 5 mL whole blood in Pink tope tube (K2-EDTA)
Testing Schedule:
Samples accepted Monday-Friday.
Turn Around Time:
12 weeks
Reference Range:
None detected
Interpretive Data:
Genes Included On TMA Panel®
CFH (Complement Factor H)
CFI (Complement Factor I)
MCP (Membrane Co-Factor Protein or CD46)
CFB (Complement Factor B)
CFHR5 (Complement Factor H Related 5)
THBD (Thrombomodulin)
C3 (Complement Component 3)
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)
PLG (Plasminogen)
DGKE (diacylglycerol kinase, epsilon)
MLPA

Multiple Ligation Probe Amplification (MLPA) is included in the testing to determine copy number variants over the complete complement Factor H related region.
Comments:
Please print, complete and submit the Kidney Testing Requisition Form from the Molecular Otolaryngology & Renal Research Laboratory, to Specimen Control/Mailouts with the specimen and the Epic Requisition.

Reasons for Testing: Genetic testing for renal disease can provide important answers to many questions. By determining the cause of renal disease, information can be provided on recurrence chance, prognosis (whether a transplant might be successful or what type of transplant is necessary, i.e. kidney only or liver/kidney), and best methods of treatment.

Indications for screening: TMA Panel® testing is recommended for patients with TMAs including HUS, aHUS and TTP. This testing is also appropriate for patients with other complement- mediated renal diseases such as C3 Glomerulonephritis and Membranoproliferative Glomerulonephritis as 6 of the genes on the panel and MLPA testing have been associated with these diseases.

Outside providers please contact MORL at 335-6623 with questions.
Methodology:
The TMA Panel® uses the newest DNA sequencing methods.
CPT Code:
81479(x11)