Cancer Mutation Profiling Blood Paired Normal Testing
Label Mnemonic: CHPNML
Epic Lab Code: LAB8080
Downtime Form: A-1a Molecular Pathology/Diagnostics Laboratory Requisition
Molecular Pathology
6004 BT GH
384-9568
Specimen(s):
Blood
Collection Medium:
Pink top tube 6 mL (K2-EDTA)
Minimum:
Collect blood in Pink top tube.
Testing Schedule:
Weekly
Turn Around Time:
21 days
Comments:
The Cancer Mutation Profiling test is a massively parallel next generation DNA sequencing-based assay that targets commonly mutated or hotspot regions of 50 cancer-related genes. Some testing requires comparison to the patient's germline sequence and a peripheral blood specimen will usually be sufficient.

Genes Assessed: ABL1, AKT1, ALK, APC, ATM, BRAF, CDH1, CDKN2A, CSF1R, CTNNB1, EGFR, ERBB2, ERBB4, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, IDH2, JAK2, JAK3, KDR, KIT, KRAS, MET, MLH1, MPL, NOTCH1, NPM1, NRAS, PDGFRA, PIK3CA, PTEN, PTPN11, RB1, RET, SMAD4, SMARC1, SMO, SRC, STK11, TP53, and VHL.
Methodology:
Massively parallel Next Generation DNA sequencing by synthesis, semiconductor technology, Ion Personal Genomics Machine
CPT Code:
81445