Sex Hormone Binding Globulin
Label Mnemonic: SHBG
Epic Lab Code: LAB4945
Downtime Form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Chemistry
6240 RCP
356-3527
Specimen(s):
Plasma
Collection Medium:
Plasma Separator Tube 4.5 mL
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
3 mL whole blood in light green top or TWO Microtainer® devices
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
1 hour (upon receipt in laboratory)
Reference Range:
Males 10-80 nmol/L
Females, non-pregnant 20-130 nmol/L

Reference ranges are not well established during pregnancy, although pregnant women tend to have markedly higher SHBG plasma concentrations due to increased estrogen production. Reference ranges in pre- pubertal children tend to be higher than adults.
Interpretive Data:
Elevated SHBG levels can be seen in elderly men, and are often found in patients with hyperthyroidism and cirrhosis of the liver. SHBG levels also increase when oral contraceptives or anti-epileptic drugs are taken. Decreased SHBG concentrations are often seen with hypothyroidism, polycystic ovarian syndrome, obesity, hirsutism, elevated androgen levels, alopecia, and acromegaly.
Comments:
This assay may be significantly impacted by high-dose biotin (>5 mg dose) taken within previous 12 hours. High concentrations of biotin may lead to falsely decreased results. These concentrations may be found in patients taking over-the-counter supplements with biotin content much higher than nutritional requirements for biotin. Specimens should not be collected until at least 12 hours after the last dose.
Methodology:
Electrochemiluminescence Immunoassay
CPT Code:
84270
 
See Additional Information:
Biotin Interference with Immunoassays