Sex Hormone Binding Globulin
|Plasma Separator Tube 4.5 mL
Call laboratory for additional acceptable specimen collection containers.
3 mL whole blood in light green top or TWO
24 hrs/day, 7 days a week, including holidays.
1 hour (upon receipt in laboratory)
Males 10-80 nmol/L
Females, non-pregnant 20-130 nmol/L
Reference ranges are not well established during pregnancy, although
pregnant women tend to have markedly higher SHBG plasma concentrations
due to increased estrogen production. Reference ranges in pre-
children tend to be higher than adults.
Elevated SHBG levels can be seen in elderly men, and are often found
in patients with hyperthyroidism and cirrhosis of the liver. SHBG
levels also increase when oral contraceptives or anti-epileptic drugs
are taken. Decreased SHBG concentrations are often seen with
hypothyroidism, polycystic ovarian syndrome, obesity, hirsutism,
elevated androgen levels, alopecia, and acromegaly.
This assay may be significantly impacted by high-dose biotin (>5 mg
dose) taken within previous 12 hours. High concentrations of biotin
may lead to falsely decreased results. These concentrations may be
found in patients taking over-the-counter supplements with biotin
content much higher than nutritional requirements for biotin.
Specimens should not be collected until at least 12 hours after the