Drugs of Abuse - Umbilical Cord
Label Mnemonic: UCDAU
Epic Lab Code: LAB7758
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Umbilical Cord
Specimen Instructions:
Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or sterile water. (Small clots of blood are acceptable - these segments of cord can be removed by reference laboratory, if necessary.) Pat the specimen dry and place in container for transport.
Minimum:
Preferred: Collect at least 6 inches of umbilical cord.

Premature infants: Send as much as possible - ability to perform full panel of testing related to weight of specimen.
Rejection Criteria:
Cords soaking in blood or other fluid. Formalin fixed. Tissue that is obviously decomposed.
Turn Around Time:
1-3 days upon receipt at reference laboratory
Reference Range:
Drugs covered and range of cutoff concentrations. Note that some drugs are identified based on the presence of unique drug metabolites not listed below. Drugs/Drug Range of Cutoff Classes Concentrations _______________________________________________________________________ Alpha-OH-Alprazolam, Alprazolam, Benzoylecgonine, 0.5 ng/g Cocaine, Codeine, Fentanyl, Hydrocodone, Hydromorphone, Morphine, Norbuprenorphine, Noroxymorphone, Oxycodone, Oxymorphone, Zolpidem 6-Acetylmorphine, 7-Aminoclonazepam, Buprenorphine 1 ng/g Buprenorphine-G, Clonazepam, Cocaethylene, Diazepam, Dihydrocodeine, Marijuana Metabolite, Methadone metabolite, Midazolam, m-OH-Benzoylecgonine, Naloxone, Nordiazepam, Norhydrocodone, Noroxycodone, Phencyclidine (PCP), Propoxyphene, Temazepam Alpha-OH-Midazolam, Meperidine, Methadone, 2 ng/g N-desmethyltramadol, O-desmethyltramadol, Oxazepam, Tapentadol, Tramadol Amphetamine, Lorazepam, MDMA (Ecstasy), Methamphetamine 5 ng/g Phentermine 8 ng/g Butalbital 25 ng/g Phenobarbital 75 ng/g
Interpretive Data:
Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during pregnancy. The pattern and frequency of drug (s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory. Glucuronide metabolites are indicated as -G.
Methodology:
Qualitative Liquid Chromatography/Tandem Mass Spectrometry/Enzyme- Linked Immunosorbent Assay
CPT Code:
80307