Drugs of Abuse - Umbilical Cord
Commercial Mailout Laboratory
(At least 8 inches, approximately the width of a sheet of paper.)
Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or water. Pat the cord dry and transport at least 8 inches of umbilical cord in a routine urine collection cup or Security Kit for Meconium/Umbilical Drug Detection.
Absolute Minimum: Collect at least 8 inches
of umbilical cord.
Premature infants: Send as much as possible - ability to perform full
panel of testing related to weight of specimen.
Cords soaking in blood or other fluid. Formalin fixed. Tissue that is
1-3 days upon receipt at reference laboratory
Drugs covered and range of cutoff concentrations. Note that some
drugs are identified based on the presence of unique drug metabolites
not listed below.
Drugs/Drug Range of Cutoff
Alpha-OH-Alprazolam, Alprazolam, Benzoylecgonine, 0.5 ng/g
Cocaine, Codeine, Fentanyl, Hydrocodone, Hydromorphone,
Morphine, Norbuprenorphine, Noroxymorphone, Oxycodone,
6-Acetylmorphine, 7-Aminoclonazepam, Buprenorphine, 1 ng/g
Clonazepam, Cocaethylene, Diazepam, Dihydrocodeine,
Methadone metabolite, Midazolam, m-OH-Benzoylecgonine,
Naloxone, Nordiazepam, Norhydrocodone, Noroxycodone,
Phencyclidine (PCP), Propoxyphene, Temazepam
Alpha-OH-Midazolam, Meperidine, Methadone, 2 ng/g
N-desmethyltramadol, O-desmethyltramadol, Oxazepam,
Amphetamine, Lorazepam, MDMA (Ecstasy), Methamphetamine 5 ng/g
Phentermine 8 ng/g
Gabapentin 10 ng/g
Butalbital 25 ng/g
Phenobarbital 75 ng/g
Marijuana Metabolite will be reported separately 0.2 ng/g
Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during approximately the last trimester of a full-term pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory.
Qualitative Liquid Chromatography/Tandem Mass Spectrometry
80326, 80347, 80364, 80355