Centromere B Antibody
| Label Mnemonic: | CENTB |
| Epic code: | LAB7828 |
| Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Chemistry
6240 RCP
356-3527
6240 RCP
356-3527
Specimen(s):
Plasma
Collection Medium:
 |
| Plasma Separator Tube 4.5 mL |
Alternate
Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around
Time:
3 hours (upon receipt in laboratory)
Reference Range:
1.0 AI (antibody index) or less
Interpretive Data:
Centromere B antibodies occur primarily in patients with the CREST
(calcinosis, Raynaud's phenomenon, esophageal hypomotility,
sclerodactyly, telangiectasia) syndrome variant of scleroderma.
Centromere B antibodies are seen in up 50% or more of patients with
CREST syndrome. A negative result for centromere B antibodies does
not rule out CREST syndrome. Centromere B antibodies have been
described in some patients with primary biliary cirrhosis, rheumatoid
arthritis, or lupus erythematosus.
The centromere B antibodies assay does not detect all centromere antibodies that may be seen on the ANA using immunofluorescence.
The centromere B antibodies assay does not detect all centromere antibodies that may be seen on the ANA using immunofluorescence.
Comments:
New assay introduced February 25, 2013.
Methodology:
Multiplex flow immunoassay
CPT Code:
86235