Centromere B Antibody
Label Mnemonic: CENTB
Epic Lab Code: LAB7828
Downtime Form: A-1a General Laboratory Requisition
Chemistry
6240 RCP
356-3527
Specimen(s):
Plasma
Collection Medium:
Plasma Separator Tube 4.5 mL
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
3 hours (upon receipt in laboratory)
Reference Range:
1.0 AI (antibody index) or less
Interpretive Data:
Centromere B antibodies occur primarily in patients with the CREST (calcinosis, Raynaud's phenomenon, esophageal hypomotility, sclerodactyly, telangiectasia) syndrome variant of scleroderma. Centromere B antibodies are seen in up 50% or more of patients with CREST syndrome. A negative result for centromere B antibodies does not rule out CREST syndrome. Centromere B antibodies have been described in some patients with primary biliary cirrhosis, rheumatoid arthritis, or lupus erythematosus.

The centromere B antibodies assay does not detect all centromere antibodies that may be seen on the ANA using immunofluorescence.
Comments:
New assay introduced February 25, 2013.
Methodology:
Multiplex flow immunoassay
CPT Code:
86235