Lyme Disease Antibodies (Acute Disease)
Label Mnemonic: LYMEA
Epic Lab Code: LAB7769
Downtime Form: A-1a Miscellaneous Request
Chemistry
6240 RCP
356-3527
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
2 mL serum
Testing Schedule:
Batch analysis (see Turn Around Time below).
Turn Around Time:
In months with low Lyme activity (September through March), testing performed on Monday and Thursday. Testing run Monday-Friday in peak season (April through August).
Reference Range:
Borrelia burgdorferi IgG Antibodies <0.2: Negative >0.2: Positive Borrelia burgdorferi IgM Antibodies <0.2: Negative 0.12 - 0.31: Equivocal >0.32: Positive Lyme Ab IgG Confirmation Negative Lyme Ab IgM Confirmation Negative
Comments:
This panel is appropriate for Lyme disease testing less than four weeks from erythema migrans or onset of disease symptoms.

If initial screen is equivocal or positive, then IgG and IgM Immunoblot will be added. Additional charges apply.

Current CDC recommendations for the serological diagnosis of Lyme disease are to screen with a polyvalent ELISA test and confirm equivocals and positives with Western blot. Both IgM and IgG Western blots should be performed on specimens obtained less than four weeks after appearance of erythema migrans or disease symptoms. Only IgG Western blot is to be performed on specimens greater than four weeks after disease onset. IgM Western blot in the chronic stage is not recommended and does not aid in the diagnosis of neuroborreliosis or chronic Lyme disease.
Methodology:
Enzyme Linked Fluorescent Assay (ELFA)/Qualitative Western Blot
CPT Code:
86618 x2 Lyme IgG/IgM; if positive add, 86617 x2 Lyme IgG/IgM