Lung Cancer, ALK FISH
Formalin Fixed, Paraffin Embedded Tissue containing Tumor (please specify case and block number on requisition)
7 days upon receipt.
An interpretative report will be provided.
A positive result (ALK rearrangement identified) is detected
when the percent of cells with an abnormality exceeds the normal cutoff
for the ALK probe set. A positive result suggests
rearrangement of the ALK locus and a tumor that may be
responsive to ALK inhibitor therapy. A negative result suggests no
rearrangement of the ALK gene region at 2p23.
Note: Decalcified tissue is not acceptable for this assay.
Useful For: Identifying patients with late-stage, non-small
cell lung cancers who may benefit from treatment with the drug
Cautions: This test is intended to be used for therapeutic
purposes in pulmonary carcinoma. This FISH assay does not rule out
other chromosome abnormalities. While results may indicate the likely
response to ALK inhibitor therapy, selection of treatment remains a
Fluorescence In Situ Hybridization (FISH)