Lung Cancer, ALK FISH
Label Mnemonic: FALK
Epic Lab Code: LAB7626
Downtime Form: A-1a Miscellaneous Request
5238 RCP
Formalin Fixed, Paraffin Embedded Tissue containing Tumor (please specify case and block number on requisition)
Turn Around Time:
7 days upon receipt.
Reference Range:
An interpretative report will be provided.
Interpretive Data:
A positive result (ALK rearrangement identified) is detected when the percent of cells with an abnormality exceeds the normal cutoff for the ALK probe set. A positive result suggests rearrangement of the ALK locus and a tumor that may be responsive to ALK inhibitor therapy. A negative result suggests no rearrangement of the ALK gene region at 2p23.
Note: Decalcified tissue is not acceptable for this assay.

Useful For: Identifying patients with late-stage, non-small cell lung cancers who may benefit from treatment with the drug Xalkori® (crizotinib).

Cautions: This test is intended to be used for therapeutic purposes in pulmonary carcinoma. This FISH assay does not rule out other chromosome abnormalities. While results may indicate the likely response to ALK inhibitor therapy, selection of treatment remains a clinical decision.
Fluorescence In Situ Hybridization (FISH)
CPT Code:
88368, 88368-26