5-HIAA
| Label Mnemonic: | 5HIAA |
| Epic code: | LAB352 |
| Downtime form: | Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
24 hr Urine More information
Specimen
Instructions:
Patients should abstain, if possible, from medications, over-the-
counter drugs, and herbal remedies for at least 72 hours prior to the
test. Twenty-four hour collections are generally recommended, but
random collections may be used. Refrigeration is the most important
aspect of specimen preservation.
Foods rich in serotonin (avocados, bananas, eggplant, pineapple, plums, tomatoes, walnuts) and medications that may affect metabolism of serotonin must be avoided at least 72 hours before and during collection of urine for HIAA.
Foods rich in serotonin (avocados, bananas, eggplant, pineapple, plums, tomatoes, walnuts) and medications that may affect metabolism of serotonin must be avoided at least 72 hours before and during collection of urine for HIAA.
Collection Medium:
) |
| Urine - 24 hour/timed plastic urine container |
Minimum:
Preferred Minimum: 4 mL aliquot from a well-mixed 24-hour urine.
Refrigerate 24-hour specimens during
collection.
Rejection Criteria:
Specimen types other than urine.
Turn Around
Time:
1-5 days upon receipt at reference laboratory
Reference Range:
5-HIAA, Urine 0.0-15.0 mg/d 5-HIAA, Urine The HIAA-to-creatinine ratio will be reported whenever the urine collection is random or other than 24 hours, or the urine volume is less than 400 mL/24 hours. 0-14 mg/g crt Creatinine (24-hour) Male 3-8 years: 140-700 mg/d 9-12 years: 300-1300 mg/d 13-17 years: 500-2300 mg/d 18-50 years: 1000-2500 mg/d 51-80 years: 800-2100 mg/d 81 years and older: 600-2000 mg/d Female 3-8 years: 140-700 mg/d 9-12 years: 300-1300 mg/d 13-17 years: 400-1600 mg/d 18-50 years: 700-1600 mg/d 51-80 years: 500-1400 mg/d 81 years and older: 400-1300 mg/d
Interpretive Data:
5-Hydroxyindoleacetic acid (5-HIAA) results are expressed as a ratio to
creatinine excretion (mg/ g crt). HIAA mass per day (mg/d) is not
reported if the urine collection is random, other than 24 hours, or for
a urine volume less than 400 mL/d.
Comments:
Collection containers available from pharmacy.
Note: Foods and medications associated with altered urinary HIAA results:
Decreased HIAA: Aspirin, chlorpromazine (Thorazine), corticotropin, dihydroxyphenylacetic acid, ethanol, gentisic acid, homogentisic acid, hydrazine derivatives, imipramine (Tofranil®), isocarboxazid (Marplan), keto acids, levodopa, MAO inhibitors, methenamine, methyldopa (Aldomet®), perchlorperazine, phenothiazines (Compazine®), promazine, promethazine (Mepergan®).
Increased HIAA: Acetaminophen, acetanilide, caffeine, coumaric acid, diazepam (Valium®), ephedrine, fluorouracil, glycerol guaiacolate (Guaifenesin), melphalan (Alkeran®), mephenesin, methamphetamine (Desoxyn), methocarbamol (Robaxin®), naproxen, nicotine, phenacetin, phenmetrazine, phenobarbital, phentolamine, rauwolfia, reserpine.
Note: Foods and medications associated with altered urinary HIAA results:
Decreased HIAA: Aspirin, chlorpromazine (Thorazine), corticotropin, dihydroxyphenylacetic acid, ethanol, gentisic acid, homogentisic acid, hydrazine derivatives, imipramine (Tofranil®), isocarboxazid (Marplan), keto acids, levodopa, MAO inhibitors, methenamine, methyldopa (Aldomet®), perchlorperazine, phenothiazines (Compazine®), promazine, promethazine (Mepergan®).
Increased HIAA: Acetaminophen, acetanilide, caffeine, coumaric acid, diazepam (Valium®), ephedrine, fluorouracil, glycerol guaiacolate (Guaifenesin), melphalan (Alkeran®), mephenesin, methamphetamine (Desoxyn), methocarbamol (Robaxin®), naproxen, nicotine, phenacetin, phenmetrazine, phenobarbital, phentolamine, rauwolfia, reserpine.
Methodology:
Quantitative High Performance Liquid Chromatography - Tandem Mass
Spectrometry
CPT Code:
83497