Multiple Sclerosis Screen Panel
Label Mnemonic: MSS
Epic Lab Code: LAB7436
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum & CSF
Specimen Instructions:
The CSF and serum samples must be collected at the same time, from the same patient.
Collection Medium:
and
Red top tube 5 mL (Clot Activator) CSF collection kit
Minimum:
Preferred Minimum: 1 mL serum in a red top and 1.5 mL CSF (both required)

Absolute Minimum: 0.5 mL serum in a red top and 0.7 mL CSF (both required)
Turn Around Time:
1-3 days upon receipt at reference laboratory
Reference Range:
Immunoglobulin G, Serum 0-30 days: 611-1542 mg/dL 1 month: 241-870 mg/dL 2 months: 198-577 mg/dL 3 months: 169-558 mg/dL 4 months: 188-536 mg/dL 5 months: 165-781 mg/dL 6 months: 206-676 mg/dL 7-8 months: 208-868 mg/dL 9-11 months: 282-1026 mg/dL 1 year: 331-1164 mg/dL 2 years: 407-1009 mg/dL 3 years: 423-1090 mg/dL 4 years: 444-1187 mg/dL 5-7 years: 608-1229 mg/dL 8-9 years: 584-1509 mg/dL 10 years and older: 768-1632 mg/dL Immunoglobulin G, CSF 0-6.0 mg/dL Albumin, CSF 0-35 mg/dL Albumin Index 0.0-9.0 CSF IgG/Albumin Ratio 0.09-0.25 IgG Index 0.28-0.66 CSF Oligoclonal Bands Negative Interpretation By report CSF IgG Synthesis Rate Less than or equal to 8.0 mg/d Albumin, Serum by Nephelometry 3500-5200 mg/dL CSF Oligoclonal Bands Number 0-1 Bands
Comments:
A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.
Methodology:
Qualitative Isoelectric Focusing/Electrophoresis/Nephelometry
CPT Code:
83916 Oligoclonal immune (Oligoclonal bands); 82784 IgG, serum; 82784 IgG CSF; 82040 Albumin, serum; 82042 Albumin, CSF