Multiple Sclerosis Screen Panel
Label Mnemonic: | MSS |
Epic code: | LAB7436 |
Downtime form: | Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Serum & CSF
Specimen
Instructions:
The CSF and serum samples must be collected
at the same time, from the same patient.
Minimum:
Preferred Minimum: 1 mL serum in a red top and 1.5 mL CSF (both
required)
Absolute Minimum: 0.6 mL serum in a red top and 1 mL CSF (both required)
Absolute Minimum: 0.6 mL serum in a red top and 1 mL CSF (both required)
Rejection Criteria:
Grossly bloody or hemolyzed specimens or severe lipemia.
Turn Around
Time:
1-3 days upon receipt at reference laboratory
Reference Range:
Effective February 16, 2021 Immunoglobulin G, Serum 0-2 years: 242-1108 mg/dL 3-4 years: 485-1160 mg/dL 5-9 years: 514-1672 mg/dL 10-14 years: 581-1652 mg/dL 15-18 years: 479-1433 mg/dL 19 years or older: 768-1632 mg/dL Immunoglobulin G, CSF 0-6.0 mg/dL Albumin, CSF 0-35 mg/dL Albumin Index 0.0-9.0 CSF IgG/Albumin Ratio 0.09-0.25 IgG Index 0.28-0.66 CSF Oligoclonal Bands Negative Interpretation By report CSF IgG Synthesis Rate Less than or equal to 8.0 mg/d Albumin, Serum 3500-5200 mg/dL CSF Oligoclonal Bands Number 0-1 Bands
Comments:
A patient is considered positive for CSF oligoclonal bands if there are
two or more bands in the CSF immunoglobulin region that are not present
in the serum. In order to confirm local production of oligoclonal IgG
in CSF, a matched serum sample is required. Oligoclonal bands present
in CSF, but not in serum, indicate central nervous system production.
Oligoclonal bands are performed using isoelectric focusing and
immunofixation.
Methodology:
Qualitative Isoelectric Focusing/Electrophoresis/Quantitative Immunoturbidimetry
CPT Code:
83916 Oligoclonal immune (Oligoclonal bands); 82784 IgG, serum; 82784
IgG CSF; 82040 Albumin, serum; 82042 Albumin, CSF