Homovanillic Acid
Label Mnemonic: HVAUR
Epic Lab Code: LAB7403
Downtime Form: A-1a General Laboratory Requisition
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Random Urine
Collection Medium:
Yellow top round bottom tube (no additive)
Minimum:
Preferred Minimum: 4 mL random urine
Absolute Minimum: 1 mL random urine

Abstain from medications for 72 hours prior to collection.
Turn Around Time:
4 working days upon receipt at reference laboratory
Reference Range:
Components Age Ref. Interval HVA, Urine 18 years and older 0.0-15.0 mg/d HVA 0-2 years 0-42 mg/g CRT 3-5 years 0-22 mg/g CRT 6-17 years 0-15 mg/g CRT 18 years and older 0-8 mg/g CRT
Interpretive Data:
Homovanillic acid (HVA) results are expressed as a ratio to creatinine excretion (mg/g cr). HVA mass per day (mg/d) is not reported on specimens from patients younger than 18 years of age, for random specimens, urine collection periods other than 24 hours, or for urine volumes less than 400 mL/d. No reference interval is available for results reported in units of mg/L.
Comments:
Moderately elevated HVA (homovanillic acid) may be caused by a variety of factors such as essential hypertension, intense anxiety, intense physical exercise, and numerous drug interactions (including some over- the-counter medications and herbal products).

Medications which may interfere with catecholamines and their metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, chlorpromazine, clonidine, disulfiram, diuretics (in doses sufficient to deplete sodium), epinephrine, glucagon, guanethidine, histamine, hydrazine derivatives, imipramine, levodopa (L-dopa, Sinemet®), lithium, MAO inhibitors, melatonin, methyldopa (Aldomet®), morphine, nitroglycerin, nose drops, propafenone (Rythmol), radiographic agents, rauwolfia alkaloids (Reserpine), and vasodilators. The effects of some drugs on catecholamine metabolite results may not be predictable.
Methodology:
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
CPT Code:
83150
 
See also:
Catecholamines, Fractionated, Random Urine
Metanephrines Total, Random Urine
Vanillylmandelic Acid, Random Urine
 
See Additional Information:
Urine Tests Requiring no Preservatives