Benzodiazepines
Label Mnemonic: BZOU
Epic Lab Code: LAB7382
Downtime Form: A-1a Miscellaneous Request
Chemistry
6240 RCP
356-3527
Specimen(s):
Urine Screen
Collection Medium:
Clear top tube
Alternate Collection Media:
Urine (Random)-BD Vacutainer®, no additive yellow top
Minimum:
5 mL random urine
Rejection Criteria:
Test cannot be added to a urine sample previously utilized for urinalysis testing (LAB1160, LAB1164, LAB8379).
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
1 hour (upon receipt in laboratory)
Reference Range:
None
Comments:
Screen includes benzodiazepines only. For full drug of abuse- urine panel, see Drug of Abuse Screen. If confirmation is needed for benzodiazepines, call the Laboratory at 356-3527. Allow up to seven days for confirmatory results. Confirmation is at an additional charge. BENZODIAZEPINES ASSAY Drug Approximate cut-off for benzodiazepines assay (ng/mL) ------------------------------------------------------------- Alprazolam* 108 Bentazepam 222 Chlordiazepoxide 146 Clobazam 123 Clonazepam* 148 Clonazolam 96 Clorazepate 124 Demoxepam 92 Deschloroetizolam 89 Diazepam 106 Diclazepam 102 Etizolam 133 Flubromazepam 79 Flubromazolam 97 Flunitrazepam 142 Flurazepam 165 Lorazepam* 163 Meclonazepam 347 Midazolam 168 Nifoxipam 375 Oxazepam 122 Pyrazolam 106 Temazepam 145 Triazolam 115 *In patients taking typical therapeutic doses of these benzodiazepines for medical purposes, the benzodiazepines screen can be negative due to the low concentrations of these drugs and their metabolites excreted in urine relative to the cut-offs. References: Belson MG, Simon HK, Sullivan K, Geller RJ. The Utility of Toxicologic Analysis in Children with Suspected Ingestion. Pediatr Emerg Care 1999;15:383-387. Bast RP, Helmer SD, Henderson SR, Rogers MA, Shapiro WM, Smith RS. Limited Utility of Routine Drug Screening in Trauma Patients. South Med J 2000;93:397-399. Hammett-Stabler CA, Pesce AJ, Cannon DJ. Urine Drug Screening in the Medical Setting. Clinica Chimica Acta 2002;315:125-135. Schiller MJ, Shumway M, Batki SL. Utility of Routine Drug Screening in a Psychiatric Emergency Setting. Psychiatric Services 2000;51:474- 478. Sugarman JM, Rodgers GC, Paul RI. Utility of Toxicology Screening in a Pediatric Emergency Department. Pediatric Emergency Care. Pediatric Emergency Care 1997;13(3):194-197.
Test Limitations:
There is the possibility that other substances and/or factors may interfere with the test and cause erroneous results (e.g., technical or procedural errors). Call the lab at 319-356-3527 for additional information.
Methodology:
Assay is based on the kinetic interaction of microparticles in a solution (KIMS) as measured by changes in light transmission.
CPT Code:
80346
 
See also:
Drugs of Abuse, Urine
Drugs of Abuse, Urine + Confirm