Anti-Müllerian Hormone
| Label Mnemonic: | AMH |
| Epic code: | LAB7364 |
| Downtime form: | Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Chemistry
6240 RCP
356-3527
6240 RCP
356-3527
Specimen(s):
Blood
Collection Medium:
 |
| Plasma Separator Tube 4.5 mL |
Minimum:
3 mL in light green top tube or TWO Microtainer®
devices
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around
Time:
1 hour (upon receipt in laboratory)
Reference Range:
Sex / Age Reference Range Females / 20 up to 25 1.22-11.7 ng/mL Females / 25 up to 30 0.890-9.85 ng/mL Females / 30 up to 35 0.576-8.13 ng/mL Females / 35 up to 40 0.147-7.49 ng/mL Females / 40 up to 45 0.030-5.47 ng/mL
Interpretive Data:
Menopausal women or women with premature ovarian failure of any cause
(including after cancer chemotherapy) will generally have very low
antimüllerian hormone (AMH), often below the lower detection
limit of quantification (0.03 ng/mL). In women with polycystic
ovarian syndrome, AMH concentrations may be two- to five-fold higher
than age-appropriate reference intervals. Reference ranges for
females less than 20 years old have not been established for this
assay. AMH concentrations in women typically reach peak values
between 18-25 years old.
Reference ranges for males have not been established for this assay. However, AMH concentration in boys up through 12 years old are generally much higher than those found in adult females. In boys with cryptorchidism, a measurable AMH concentration is predictive of undescended tests, while an undetectable value is suggestive of anorchia or functional failure of the abnormally sited gonad.
Test Limitations:
Cetrotide, Ovitrelle, Endometrin, and Follistatin may interfere with this AMH immunoassay. Do not measure AMH within 2 weeks of using these products.
The assay is unaffected by icterus (bilirubin is less than 66 mg/dL), hemolysis (Hb is less than 1,000 mg/dL), lipemia (Intralipid is less than 1000 mg/dL) and biotin is less than 1200 ng/mL. (criterion: recovery within plus or minus 10% of initial value).
Reference ranges for males have not been established for this assay. However, AMH concentration in boys up through 12 years old are generally much higher than those found in adult females. In boys with cryptorchidism, a measurable AMH concentration is predictive of undescended tests, while an undetectable value is suggestive of anorchia or functional failure of the abnormally sited gonad.
Test Limitations:
Cetrotide, Ovitrelle, Endometrin, and Follistatin may interfere with this AMH immunoassay. Do not measure AMH within 2 weeks of using these products.
The assay is unaffected by icterus (bilirubin is less than 66 mg/dL), hemolysis (Hb is less than 1,000 mg/dL), lipemia (Intralipid is less than 1000 mg/dL) and biotin is less than 1200 ng/mL. (criterion: recovery within plus or minus 10% of initial value).
Comments:
Assay updated with increased tolerance to biotin on 2/21/23.
Methodology:
Electrochemiluminescence Immunoassay (ECLIA)
CPT Code:
83520
See Additional Information:
Biotin Interference with Immunoassays
Biotin Interference with Immunoassays