MT-TS1 Gene Analysis Common Variants
Commercial Mail-out Laboratory
|Pink top tube 6 mL (K2-EDTA)
||Pink top tube 6 mL (K2-EDTA)
Preferred Minimum: 8 mL whole blood
Absolute Minimum: 4 mL whole blood
The A7445G mutation in the MTTS1 gene, which encodes the transfer RNA for serine, is associated with maternally inherited, nonsyndromic
hearing loss (Reid et al., 1994). The deafness is progressive, post
lingual and involves the high frequencies.
Sensitivity is greater than 99%.
Please print, complete and submit the Hearing Loss Testing Requisition Form
from the Molecular
Otolaryngology & Renal Research Laboratory, to Specimen
Control/Mailouts with the specimen and the Epic Requisition.
Samples are amplified with an oligonucleotide primer pair that flanks
the A7445G mutation within the MTTS1 gene, followed by sequencing.