Quetiapine Drug Level

Label Mnemonic:	SEROQ
Epic code:	LAB7286
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Plasma

Collection Medium:

Lavender top tube 3 mL (EDTA)

Minimum:

Preferred Minimum: 1 mL plasma

Rejection Criteria:

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Delivery Instructions:

Deliver to laboratory within 1 hour of collection.

Testing Schedule:

Wednesdays

Turn Around Time:

1-8 days upon receipt at reference laboratory

Reference Range:

Therapeutic Range: 100–1000 ng/mL

Toxic: Greater than 1000 ng/mL

Interpretive Data:

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. The pharmacokinetics of quetiapine are influenced by drug-drug interactions that may inhibit or induce CYP3A4 metabolism. Adverse effects to quetiapine therapy may include somnolence, hypotension, dizziness, neuroleptic malignant syndrome, tardive dyskinesia, and weight gain.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.

Methodology:

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

CPT Code:

80342