Tricyclic Multi-Drug Screen
Label Mnemonic: TADID
Epic Lab Code: LAB7285
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Plasma
Specimen Instructions:
Timing of specimen collection: Pre-dose (trough) draw - At steady- state concentration.
Collection Medium:
Lavender top tube 3 mL (EDTA)
Minimum:
Preferred Minimum: 1 mL plasma
Rejection Criteria:
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Turn Around Time:
1-5 days upon receipt at reference laboratory.
Reference Range:
Drug Therapeutic Range Toxic Amitriptyline (Elavil, Vanatrip) Not established Not established Nortriptyline (Aventyl, Pamelor) 50-150 ng/mL > 500 ng/mL Total Amitriptyline + Nortriptyline 95-250 ng/mL > 500 ng/mL Imipramine (Tofranil) Not established Not established Desipramine (Norpramin) 100-300 ng/mL > 500 ng/mL Total Imipramine + Desipramine 150-300 ng/mL > 500 ng/mL Doxepin (Sinequan, Zonalon) Not established Not established Nordoxepin Not established Not established Total Doxepin + Nordoxepin 100-300 ng/mL > 500 ng/mL Protriptyline (Vivactil) 70-240 ng/mL > 400 ng/mL Clomipramine (Anafranil) Not established Not established Norclomipramine Not established Not established Total Clomipramine + Norclomipramine 220-500 ng/mL > 900 ng/mL
Comments:
Note: This test is used to quantitate the following tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, norclomipramine, nordoxepin, nortriptyline, and protriptyline.
Methodology:
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
CPT Code:
80337