Drugs of Abuse Screen

Label Mnemonic:	DRUGSCR
Epic code:	LAB5705
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Plasma

Specimen Instructions:

Plasma is preferred over serum. Cocaine and cocaethylene are more stable in fluoride-preserved plasma than serum.

Collection Medium:

	and
Pink top tube 6 mL (K2-EDTA)	and	Pink top tube 6 mL (K2-EDTA)

Minimum:

Preferred Minimum: 4 mL plasma
Absolute Minimum: 3 mL plasma

Rejection Criteria:

Specimens exposed to repeated freeze/thaw cycles. Separator tubes. Plasma or whole blood collected in lt. blue (sodium citrate). Hemolyzed specimens.

Delivery Instructions:

Submit specimen to laboratory as soon as possible after collection.

Turn Around Time:

Screen: 1-2 days upon receipt at reference laboratory
Confirmation: 1-4 days upon receipt at reference laboratory

Reference Range:

Drugs/Drug Classes           Screen
Amphetamines                 20 ng/mL
Methamphetamine              20 ng/mL
Barbiturates                 50 ng/mL
Benzodiazepines              50 ng/mL
Buprenorphine                 1 ng/mL
Cocaine                      20 ng/mL
Marijuana                    20 ng/mL
Methadone and metabolite     25 ng/mL
Opiates                      20 ng/mL
Oxycodone                    20 ng/mL
Phencyclidine                10 ng/mL

Interpretive Data:

Drugs/Drug classes reported as "Positive" are automatically reflexed to mass spectrometry confirmation/quantitation. An unconfirmed positive immunoassay screen result may be useful for medical purposes but does not meet forensic standards. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration at which the screening test can detect a drug or metabolite varies within a drug class. Specimens for which drugs or drug classes are detected by the screen are automatically reflexed to a second, more specific technology (GC/MS and/or LC-MS/MS). The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

For medical purposes only; not valid for forensic use.

Comments:

Note: Screen-positive specimens are automatically confirmed by GC/MS and/or LC-MS/MS; additional charges may apply.

Methodology:

Enzyme Immunoassay/Gas Chromatography-Mass Spectrometry/Liquid Chromatography-Tandem Mass Spectrometry

CPT Code:

80307 Screen; if positive add appropriate CPT code for drug confirmed: 80349 Marijuana; 80353 Cocaine; 80361 Opiates; 83992 Phencyclidine; 80324 Amphetamines; 80345 Barbiturates; 80358 Methadone; 80346 Benzodiazepine; 80348 Buprenorphine