Mannose Binding Lectin
Commercial Mailout Laboratory
Separate specimens must be submitted when multiple tests are ordered.
|Red top tube 5 mL (Clot Activator)
Preferred minimum: 1 mL serum
Absolute minimum: 0.2 mL serum
Specimens collected in EDTA or citrate. Contaminated or heat-
1-8 days upon receipt at reference laboratory
Greater than 50 ng/mL
Mannose-binding protein is a component of the innate or natural immune
system which binds to mannose residues on a variety of different
microorganisms. When bound, this lectin will trigger the complement
pathway resulting in opsonization. Mannose-binding protein is also an
acute phase reactant produced by the liver. Patients who have abnormal
levels of mannose-binding protein may have recurrent significant
infections in the absence of abnormalities in the four major arms of
the immune system. Abnormal mannose-binding protein concentrations have
been found in patients with infectious disorders such as tuberculosis,
hepatitis B, and in autoimmune disorders including recurrent
spontaneous abortion and systemic lupus erythematosis.
This test is used as an initial screening for suspected deficiency in
the lectin complement pathway.
Quantitative Enzyme-Linked Immunosorbent Assay