Mannose Binding Lectin
Label Mnemonic: MBL
Epic Lab Code: LAB4490
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Specimen Instructions:
Separate specimens must be submitted when multiple tests are ordered.
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred minimum: 1 mL serum
Absolute minimum: 0.2 mL serum
Rejection Criteria:
Specimens collected in EDTA or citrate. Contaminated or heat- inactivated specimens.
Delivery Instructions:
Submit specimen to laboratory as soon as possible after collection.
Turn Around Time:
1-8 days upon receipt at reference laboratory
Reference Range:
Greater than 50 ng/mL
Interpretive Data:
Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis, hepatitis B, and in autoimmune disorders including recurrent spontaneous abortion and systemic lupus erythematosis.
Comments:
This test is used as an initial screening for suspected deficiency in the lectin complement pathway.
Methodology:
Quantitative Enzyme-Linked Immunosorbent Assay
CPT Code:
83520