Mannose Binding Lectin

Label Mnemonic:	MBL
Epic code:	LAB4490
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Specimen Instructions:

Separate specimens must be submitted when multiple tests are ordered.

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred minimum: 1 mL serum
Absolute minimum: 0.2 mL serum

Rejection Criteria:

Specimens collected in EDTA or citrate. Contaminated or heat- inactivated specimens.

Delivery Instructions:

CRITICAL FROZEN.

Turn Around Time:

1-8 days upon receipt at reference laboratory

Reference Range:

Greater than 50 ng/mL

Interpretive Data:

Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis, hepatitis B, and in autoimmune disorders including recurrent spontaneous abortion and systemic lupus erythematosis.

Comments:

This test is used as an initial screening for suspected deficiency in the lectin complement pathway.

Methodology:

Quantitative Enzyme-Linked Immunosorbent Assay

CPT Code:

83520