Mannose Binding Lectin
Label Mnemonic: MBL
Epic code: LAB4490
Downtime form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mailout Laboratory
6240-8 RCP
Specimen Instructions:
Separate specimens must be submitted when multiple tests are ordered.
Collection Medium:
Red top tube 5 mL (Clot Activator)
Preferred minimum: 1 mL serum
Absolute minimum: 0.2 mL serum
Rejection Criteria:
Specimens collected in EDTA or citrate. Contaminated or heat- inactivated specimens.
Delivery Instructions:
Turn Around Time:
1-8 days upon receipt at reference laboratory
Reference Range:
Greater than 50 ng/mL
Interpretive Data:
Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis, hepatitis B, and in autoimmune disorders including recurrent spontaneous abortion and systemic lupus erythematosis.
This test is used as an initial screening for suspected deficiency in the lectin complement pathway.
Quantitative Enzyme-Linked Immunosorbent Assay
CPT Code: