Adenosine Deaminase, RBC

Label Mnemonic:	ADA
Epic code:	LAB4482
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Whole Blood

Collection Medium:

Lavender top tube 3 mL (EDTA)

Minimum:

Preferred Minimum: 3 mL whole blood in a lavender top tube
Absolute Minimum: 1 mL whole blood in a lavender top tube

Rejection Criteria:

Hemolyzed specimens

Delivery Instructions:

Submit specimen to laboratory as soon as possible after collection.

Turn Around Time:

1-4 days upon receipt at reference laboratory

Reference Range:

400-900 mU/g Hb

Interpretive Data:

Adenosine Deaminase (ADA) deficiency is an autosomal recessive disorder of purine metabolism primarily affecting lymphocyte development, viability, and function. Affected individuals have less than 1 percent of normal ADA catalytic activity in red cell hemolysates. ADA deficiency is the cause of 20-30 percent of SCID cases. If the patient has been recently transfused, ADA deficiency may be masked; interpret results with caution. Heterozygotes cannot be identified by this test. If clinical suspicion remains, consider testing to determine the ADA genotype: Severe Combined Immunodeficiency (SCID) Panel, Sequencing and Deletion/Duplication, 19 Genes.

Methodology:

Spectrophotometry

CPT Code:

84311