Adenosine Deaminase, RBC
Label Mnemonic: ADA
Epic Lab Code: LAB4482
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Whole Blood
Collection Medium:
Lavender top tube 3 mL (EDTA)
Minimum:
Preferred Minimum: 3 mL whole blood in a lavender top tube
Absolute Minimum: 1 mL whole blood in a lavender top tube
Rejection Criteria:
Hemolyzed specimens
Delivery Instructions:
Submit specimen to laboratory as soon as possible after collection.
Turn Around Time:
1-4 days upon receipt at reference laboratory
Reference Range:
400-900 mU/g Hb
Interpretive Data:
Adenosine Deaminase (ADA) deficiency is an autosomal recessive disorder of purine metabolism primarily affecting lymphocyte development, viability, and function. Affected individuals have less than 1 percent of normal ADA catalytic activity in red cell hemolysates. ADA deficiency is the cause of 20-30 percent of SCID cases. If the patient has been recently transfused, ADA deficiency may be masked; interpret results with caution. Heterozygotes cannot be identified by this test. If clinical suspicion remains, consider testing to determine the ADA genotype: Severe Combined Immunodeficiency (SCID) Panel, Sequencing and Deletion/Duplication, 19 Genes.
Methodology:
Spectrophotometry
CPT Code:
84311