Sertraline (Zoloft) Drug Level
Label Mnemonic: SERT
Epic Lab Code: LAB4045
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Specimen Instructions:
Timing of specimen collection: Pre-dose (trough) draw At steady state concentration.
Collection Medium:
Red top tube 5 mL (Clot Activator)
Minimum:
Preferred Minimum: 1 mL serum
Rejection Criteria:
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Delivery Instructions:
Submit specimen to laboratory as soon as possible after collection.
Turn Around Time:
1-5 days upon receipt at reference laboratory.
Reference Range:
Therapeutic Range: Not well established. Toxic: > 300 ng/mL
Interpretive Data:
Sertraline doses ranging from 50-200 mg/d produce serum concentration ranging from 30-200 ng/mL. Dosing above 200 mg/d is associated with increased adverse effects and decreased efficacy. Adverse effects may include dry mouth, headache, dizziness, somnolence, nausea and diarrhea.
Methodology:
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
CPT Code:
80332