Leflunomide as Metabolite Drug Level
| Label Mnemonic: | TERI |
| Epic code: | LAB3489 |
| Downtime form: | Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Serum
Specimen
Instructions:
Draw blood no sooner than 12 hours (trough
value) after last dose.
Collection Medium:
 |
| Red top tube 5 mL (Clot Activator) |
Minimum:
Preferred Minimum: 1.0 mL serum from red top tube
Rejection Criteria:
Gross Hemolysis and Lipemia.
Delivery Instructions:
Deliver to laboratory immediately after collection.Turn Around
Time:
2-5 days upon receipt at reference laboratory
Reference Range:
Therapeutic: >40 mcg/mL
Elimination: <0.020 mcg/mL
Elimination: <0.020 mcg/mL
Interpretive Data:
Therapy: clinical targets for serum teriflunomide (leflunomide
metabolite) concentrations are still being determined, but levels >40
mcg/mL appear to correlate with better outcome.
Elimination: serum concentrations <0.020 mcg/mL (20 ng/mL) are preferred to minimize potential teratogenesis for patients considering pregnancy.
Elimination: serum concentrations <0.020 mcg/mL (20 ng/mL) are preferred to minimize potential teratogenesis for patients considering pregnancy.
Comments:
Useful For:
Therapeutic monitoring of patients actively taking leflunomide
Assessment of elimination in patients requiring enhanced elimination of the drug
Therapeutic monitoring of patients actively taking leflunomide
Assessment of elimination in patients requiring enhanced elimination of the drug
Methodology:
High-Turbulence Liquid Chromatography Mass Spectrometry (HTLC-MS/MS)
CPT Code:
80193