C-erb-2 Oncoprotein
Label Mnemonic: ICERB
Epic code: LAB1915
Downtime form: H-1 Surgical Pathology Consult
Immunopathology
5238 RCP
356-2688
Specimen(s):
Tissue
Collection Medium:
Tissue Block
Testing Schedule:
0800-1630 Monday through Friday. For additional services, contact Clinical Pathology Resident on-call at pager #3404.
Turn Around Time:
3 days
Reference Range:
The pathologist will provide an interpretative report.
Comments:
Please send a Surgical Pathology H-1 form to Immunopathology with 
this request.

C-erb-2 oncoprotein is the product of the HER-2 (neu) oncogene which 
is overexpressed in a variety of adenocarcinomas arising at various 
sites. Overexpression of c-erb-2 is present in 15-30% of cases of 
breast carcinoma and has been demonstrated to be a negative prognostic 
indicator.

C-erb-2 overexpression can be detected by immunohistochemical staining 
of formalin-fixed paraffin-embedded sections of tumor tissue. Membrane 
staining of the cells is the only reaction considered positive. A 
positive therapeutic response to Herceptin (TM) therapy with 
anti-C-erb-2 monoclonal antibody has been reported in association with 
3+ staining intensity.
Methodology:
Immunohistochemistry
CPT Code:
88360 Cerb-2, 88360-26 Cerb-2 Professional Interpretation