C-erb-2 Oncoprotein
Label Mnemonic: ICERB
Epic Lab Code: LAB1915
Downtime Form: H-1 Surgical Pathology Requisition
Immunopathology
5238 RCP
356-2688
Specimen(s):
Tissue
Testing Schedule:
0800-1630 Monday through Friday. For additional services, contact Clinical Pathology Resident on-call at pager #3404.
Turn Around Time:
3 days
Reference Range:
The pathologist will provide an interpretative report.
Comments:
Please send a Surgical Pathology H-1 form to Immunopathology with this request. C-erb-2 oncoprotein is the product of the HER-2 (neu) oncogene which is overexpressed in a variety of adenocarcinomas arising at various sites. Overexpression of c-erb-2 is present in 15-30% of cases of breast carcinoma and has been demonstrated to be a negative prognostic indicator. C-erb-2 overexpression can be detected by immunohistochemical staining of formalin-fixed paraffin-embedded sections of tumor tissue. Membrane staining of the cells is the only reaction considered positive. A positive therapeutic response to Herceptin (TM) therapy with anti-C-erb-2 monoclonal antibody has been reported in association with 3+ staining intensity.
Methodology:
Immunohistochemistry
CPT Code:
88360 Cerb-2, 88360-26 Cerb-2 Professional Interpretation